What Drug Is Most Effective For Early Ejaculation?

early ejaculation causes

Thought PE is common the treatment options differ from case to case. The Early Ejaculation Causes and the individual circumstances also play a role in determining the treatment.

People who suffer from this ailment need not worry. All they have to do is consult a sexual health expert for advice about the best treatment for their specific condition.

1. Common Drugs to Effectively Treat Early Ejaculation Causes

Early orgasm afflicts men. There are many drugs and treatments to help manage this condition. Of course, one should only choose the most suitable one after consulting a healthcare professional, because the treatment options depend on the underlying causes of each person’s own condition and his own health needs.

The following are the common drugs and treatment options for the early release of semen:


Certain antidepressant medications, such as sertraline (Zoloft), paroxetine (Paxil), and Dapoxetine (Priligy), have proven to be effective in delaying the release of semen by increasing the serotonin levels in the brain.

Only one’s healthcare professional can provide guidance about proper usage, potential side effects, and the long-term effectiveness of the drugs mentioned above after understanding early ejaculation causes.

Tricyclic Antidepressants

Some healthcare professionals prescribe medications like clomipramine (Anafranil) to Treat the Quick Peak in Sexual Activity.

Topical Anesthetics

One can apply prescription topical anesthetics like lidocaine or benzocaine creams and sprays or over-the-counter ones to the penis to reduce sensitivity and prolong unintentional climax.

PDE-5 Inhibitors

Some men find that Viagra, Cialis, or Vardenafil can help with untimely ejaculation. However, medical professionals prescribe them to people who suffer from erectile dysfunction. 

Behavioral Therapies

One can learn techniques such as the stop-start method and the squeeze technique with a therapist’s help. These help improve ejaculatory control.

Counseling or Psychotherapy

Some abrupt climax cases may be related to psychological issues or relationship problems. Therapy or counseling can help address these issues.

Natural Supplements

Sometimes, people use natural Supplements for Premature Ejaculation, such as 5-hydroxytryptophan (5-HTP), or herbal remedies like ginseng and ginkgo biloba, to treat the condition. 

Kegel Exercises

These exercises may help them gain better control over their ejaculatory reflex.

Combination Therapies

Sometimes, a combination of medication and behavioral therapy is the most effective approach to managing premature ejaculation. 

2. Effectiveness of Each Drug Type

Premature ejaculation can adversely impact people’s quality of life and relationships. The following are the most commonly-used drugs and treatments for premature ejaculation:


SSRIs are antidepressants that can be effective in delaying ejaculation. PCPs commonly prescribe such medications as fluoxetine, paroxetine, and sertraline off-label for this purpose. They increase serotonin levels in the brain. That could help delay ejaculation. However, they have side effects, including sexual dysfunction.


Medical professionals specifically approve dapoxetine for some early ejaculation causes in some countries. It is a short-acting SSRI. Therefore, a person can take it as needed. While dapoxetine is effective in increasing the time to ejaculation, it may also have side effects such as dizziness, headaches, and nausea.

Topical Anesthetics

There are some topical creams and sprays that contain lidocaine or prilocaine. While these products are effective, they could also cause reduced sensation and potential transfer to the partner, hampering sexual satisfaction.

Behavioral Therapy

Behavioral therapy techniques, such as the stop-start technique and the squeeze technique, are non-pharmacological approaches to treating speedy sexual finish. They involve specific exercises and methods that help improve ejaculatory control. If one practices them consistently, they can be effective.

PDE-5 Inhibitors

People primarily use Viagra, Cialis and Levitra to treat erectile dysfunction. However, they may also help some men with unintentional climaxes. These medications work by improving the blood flow to the penis and could prolong ejaculation.


Tramadol is an opioid-like medication used off-label to treat ED and early ejaculation causes. However, one should use it with caution due to its potential for addiction and the side effects.

Natural Supplements

There are some natural remedies and herbal supplements for premature ejaculation. These include ashwagandha, L-arginine, and ginseng. While some people may find them helpful, there is limited scientific evidence supporting their efficacy.Moreover, early ejaculation causes could be physical and psychological. Therefore, it may be necessary to address the underlying factors, including anxiety and relationship issues.

A urologist or sexologist may provide a tailored approach to managing abrupt climax.

Learn more: What is the Latest Treatment for Erectile Dysfunction?

3. Considerations when Choosing a Drug

A person must consider many factors while choosing the appropriate medication or treatment for PE.

These are as follows:

Seek a medical professional’s help

Before one commences any treatment, he must visit a urologist or a sexual health specialist to understand the early ejaculation causes. The medical practitioner will help diagnose the underlying causes and determine the course of treatment appropriate to each specific case.

Identify the cause

Early ejaculation causes could be psychological or physiological. While anxiety and relationship issues are examples of the former, hypersensitivity is an example of the latter. One must identify the root cause to select the right treatment.

Lifestyle changes

Sometimes, modifications to a person’s lifestyle can help manage the involuntary release of semen. These include exercises like Kegels, reducing stress, abstaining from excessive alcohol and smoking, and maintaining a healthy lifestyle.

Behavioral Therapy

The stop-start technique, the squeeze technique, and other methods of behavioral therapy can help manage early ejaculation causes effectively. People who adopt these must do specific exercises and communicate with their partners.

Topical Anesthetics

Some men apply over-the-counter or prescription topical anesthetics, such as numbing creams or sprays, to the penis to reduce sensitivity and delay ejaculation. But they must only use these as per a doctor’s guidance.


Some medications are specially designed to treat PE. The most common ones are:


To delay ejaculation, doctors prescribe antidepressants like paroxetine and sertraline off-label. 


A person should take dapoxetine, an SSRI used to treat premature ejaculation in some countries – as required. Its effects are rapid, but it could have side effects.

Combination Therapies

A combination of treatments, such as medications and behavioral therapy, may, in some cases, be more effective in managing PE.

Potential Side Effects

One should take into account the potential side effects and risks associated with any treatment. However, he should discuss these with his healthcare provider.

Cost and Availability

Some treatments are expensive, not covered by insurance or not universally available. People who suffer from the fast release of semen should consider the cost and availability of the treatment options.

Partner’s Involvement

The involvement of a partner in the treatment could be beneficial. In any case, the couple must have open communication with and mutually support each other. 

People who suffer from PE must work with a healthcare professional to tailor treatment plans as per their early ejaculation causes and needs. It is possible to manage this sexual issue by adopting the right approach. 

4. Potential Side Effects and Safety

While there are many medications and treatments on the market for premature orgasm, one should not use any of them without a qualified medical professional’s advice, because only they can assess each individual case and prescribe the best treatment option.

SSRIs are among the most common medications used to treat premature ejaculation. In some countries, people use dapoxetine to treat the condition.


SSRIs, such as dapoxetine, are safe if taken as prescribed and under medical supervision. However, they are not suitable for everyone. People must inform their healthcare providers about their medical history, current medications, if any, and allergies, if any, to ensure the drug is safe and appropriate for them.

Side Effects

The SSRIs for PE have potential side effects. These include:


People on these medications could feel dizzy or lightheaded.

Dry Mouth

Some people could experience a dry mouth.


Headaches are commonly associated with SSRIs.


Some people may feel nauseous while taking these medications.

Not everyone will experience these side effects. Moreover, they are temporary and mild. But if a person experiences severe or persistent side effects, he should seek a healthcare provider’s appointment.

Besides SSRIs, there is a class of medications called topical anesthetics. 

Before starting any medication related to a premature sexual climax, one must seek a doctor’s guidance about the most suitable treatment based on their individual circumstances. The medical professional will also monitor for potential side effects and explore other non-pharmacological treatment strategies, such as behavioral therapy and counseling, which may be effective in addressing premature ejaculation.

5. Dosage and Administration

Depending on the specific medication a doctor has prescribed, the dosage and administration of medication may vary as per the various  early ejaculation causes. Dapoxetine is one of the most commonly used medications for this condition. One must follow the medical professional’s instructions and specific guidelines mentioned in the prescription.

Dapoxetine Dosage and Administration


The medical expert will assess the patient’s condition and medical history to decide if it would be appropriate to use dapoxetine to treat him. 

Starting Dose

The typical starting dose for dapoxetine is 30mg. One should wait one to three hours before having sex. 

Maximum Daily Dose

Healthcare professionals usually recommend a maximum dose of 60mg of dapoxetine daily. However, the patient should not exceed that amount in a 24-hour period.

Take it with Water

To aid in absorption, one should take dapoxetine with a full glass of water.


The medication is not for daily use. One should take it on an as-needed basis, 1-3 hours before sexual activity.


Taking dapoxetine with or without food is a matter of personal choice, but one should preferably not take it with a high-fat meal.


Ideally, one should avoid consuming alcohol while on dapoxetine because it could increase the risk of side effects and reduce the medication’s effectiveness.

Side Effects

A person should be aware of the potential side effects, including diarrhea, dizziness, headaches, and nausea. If he experiences severe or bothersome side effects, he should consult a doctor.


One should inform his healthcare provider about all the medications he is on to avoid any adverse interactions.


One should follow up with his medic regularly to assess the drug’s effectiveness and discuss any adjustments in the dosage or treatment plan.

Early ejaculation causes can be varied and underlying . Dapoxetine is just one of the many treatment options one can avail of. One must have an open and honest discussion with his healthcare provider about his condition and the preferred treatment option to determine which is most suitable for him. 

6. Tips for Effective PE Management

Untimely ejaculation can be frustrating. One must note that the condition has psychological and physical causes. The tips for its management are as under :

Kegel Exercises

Strengthening one’s pelvic floor muscles by performing Kegel exercises can help a person gain better control over their ejaculation. To do the exercises, one should contract the muscles that he uses to stop his urine flow, hold for a few seconds, and release. He should repeat these several times a day.

Practice the Start-Stop Technique

While a man is having sex, or when he is about to ejaculate, he should stop all stimulation and take a break until the urge subsides before resuming. This will help the person become more aware of his body’s responses and gain better control.

The Squeeze Technique

This technique involves a man’s partner squeezing the base of his penis for about 30 seconds when he is about to ejaculate. When the sensation subsides, he can resume. One should repeat the procedure as required.

Mindfulness and Relaxation

Anxiety and stress are one of the main early ejaculation causes. One should practice relaxation techniques, such as deep breathing and meditation, to reduce stress and help him stay calm while having sex. 

Sex Therapy

A person could visit a sex therapist or counselor specializing in sexual issues. He will help him address the psychological factors contributing to the condition and guide him through techniques to improve control.

Desensitizing Creams or Sprays

Over-the-counter desensitizing products temporarily reduce sensitivity. However, one should use them with caution and in moderation, lest they reduce pleasure for both partners.


One could opt for a thicker condom or one with a desensitizing agent to reduce sensitivity and prolong ejaculation. Experimenting with a variety of brands and styles will help him know which one works best for him.

Prescription Medications

In some cases, a healthcare professional may prescribe SSRIs to help delay ejaculations. These are typically off-label and used specifically for this purpose.

Lifestyle Changes

It is imperative that a person follow a healthy lifestyle, which includes a balanced diet, regular exercise, and sufficient sleep. Reducing alcohol consumption and tobacco use could also improve one’s sexual performance.


One must communicate with his partner and be open and honest about everything. He should share his concerns and work with her to find solutions that both of them are comfortable with. 


One should practice control while masturbating. Only then will he improve his ability to delay ejaculation. Every person must try to increase the time it takes to reach orgasm gradually.

Educating oneself

One should learn about his body’s sexual response and the factors that contribute to premature ejaculation. The knowledge can help a person make an informed choice and take control of their sexual health.

Managing PE usually involves trial and error to arrive at the strategies best suited to each person. If the problem is chronic or worsens, one should consult a doctor or sex therapist and seek personalized assistance.

Related – Top 8 Oral Jelly for Erectile Dysfunction in Men


Medication can be a viable option to manage PE. It should be a part of a comprehensive approach that may include counseling, communication with one’s partner, and lifestyle changes. One should consult a doctor for a personalized treatment plan and understand the early ejaculation causes.  


Yes. There are prescription medications that one can use to treat early ejaculation.

Early ejaculation medications work in various ways. Some increase serotonin levels in the brain, and others are topical anesthetics that reduce sensitivity in the genital area, thereby allowing for longer-lasting intercourse.

Selective serotonin reuptake inhibitors (SSRIs) like dapoxetine, topical creams or sprays with lidocaine or prilocaine, and tricyclic antidepressants like clomipramine are the most well-known medications for early ejaculation.


  • Open communication
  • Incorporate modifications to their lifestyle
  • Enroll in therapy
  • Use lubricant or a device while having sex.

In most cases, he will need a healthcare provider’s prescription to purchase early ejaculation medications.

They may help some people significantly extend the time before they ejaculate; others may find modest improvement.

Yes. As is the case with all other medications, early ejaculation medications may have side effects. The most common of them include changes in sexual desire, dizziness, and nausea. A person should discuss the potential side effects with his healthcare provider.

The duration of the medication can vary depending on the type of medication and a person’s individual needs. One’s healthcare professional will guide him on how long he should take it.

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