Sildenafil vs Tadalafil – Which is the Better Option?

Sildenafil vs Tadalafil


Here in this blog, We compare sildenafil vs tadalafil drugs used to Treat Erectile Dysfunction i.e. ED. Reading this blog will give you a better understanding of both these drugs and help you choose which is right for you.

What is Erectile Dysfunction (ED)?

When a man doesn’t have enough strength to hold his penis erect to have sex for sufficient time and this problem is persistent for a considerable time it is called ED. There can be many layers to this problem and should be treated under proper professional guidance.

Sildenafil for Erectile Dysfunction: The Benefits and Mechanism of Action

– What is Sildenafil?

Sildenafil is made to help men who have trouble getting or having an erection strong enough to satisfy sexual intercourse.

This drug manages proper blood flow to the penis. As the blood flow is better, the penis can stand up and stay that way for longer. This makes the sexual experience more satisfying for both parties.

Sildenafil is generally taken by mouth in the form of a pill, and it usually starts to work between 30 minutes and an hour later. 

– How Does Sildenafil Work?

Sildenafil helps blood flow to the penis, In ED, the penis loses the strength to get or hold an erection due to insufficient blood flow. When we look at Sildenafil vs Tadalafil usually, Sildenafil works by stopping PDE5, which is an enzyme. Normally, this enzyme breaks down a drug called cGMP, which keeps the blood vessels in the penis open and relaxed. By stopping PDE5, Sildenafil lets cGMP build up, which makes the penis get more blood.

So, when a man takes Sildenafil, it helps the blood vessels in the penis stay open and relaxed for a longer time. This lets more blood flow into the penis, because of this a man gets enough strength to get and hold an erection. It is important to remember that Sildenafil only works when a guy is sexually aroused and it doesn’t help in getting aroused. 

– Benefits of Sildenafil

  • Helps with erections: When men want to have sex, Sildenafil makes their erections better and last longer. 
  • Increases sexual satisfaction: Sildenafil can increase sexual satisfaction and pleasure for both parties by improving erectile function.
  • Increases confidence: Sildenafil can boost a man’s confidence and self-esteem by reassuring him that he can have a happy sexual experience.
  • Helps in relationships: When sildenafil is used to treat erectile dysfunction, it can make the sexual connection between two people healthier and more satisfying.
  • Restores intimacy: Sildenafil helps men get back to being able to have sex, which can help their relationships become closer and more intimate again.

Tadalafil for ED: The Benefits and Mechanism of Action

– What is Tadalafil?

Tadalafil is a Medicine that helps men with erectile dysfunction (ED) get or keep an erection. It works by sending more blood to the penis, which makes it easier to get and keep a strong erection when a man wants to have sex. 

– How Does Tadalafil Work?

The PDE5 enzyme is blocked by tadalafil, which makes more blood flow to the penis. All it does is strengthen the penis with proper blood flow so that it can stay erect to have satisfying sexual intercourse. 

– Benefits of Tadalafil

  • Tadalafil helps men have erections that are better and last longer when they want to have sex.  Increased Sexual Happiness: Because tadalafil improves erectile function, it can make both partners feel more happy and fulfilled.
  • Longer-Lasting Benefits: Tadalafil’s benefits can last longer than those of other medicines for ED. It can work for up to 36 hours, which gives guys more time to do sexual things.
  • Increased spontaneity: Because tadalafil lasts longer, you can be more flexible and spontaneous in your sexual actions. Men don’t have to plan their lives as much around taking their medicine.
  • Improved Confidence: Tadalafil can boost a man’s confidence and self-esteem by making him feel like he can have a satisfying sexual experience without thinking about ED.

Comparing Sildenafil VS Tadalafil

Comparing Sildenafil vs Tadalafil in Terms of Their Time to Take Effect

  1. Sildenafil: It usually starts to work 30 to 60 minutes after you take it, but this can vary from person to person. Most of the time, the activity lasts between 4 and 6 hours.
  2. Tadalafil takes longer to start working, usually between 1 and 2 hours after taking it. But it can work for up to 36 hours, which is a lot longer than most other drugs. People sometimes call Tadalafil the “weekend pill” because it works for a long time.

Flexibility in Dosing of Sildenafil vs tadalafil:


  • What is the flexibility in dosing sildenafil vs tadalafil
  1. Sildenafil comes in 25 mg, 50 mg, and 100 mg tablets, among other levels. The starting amount is usually 50 mg, but this can be changed based on how each person responds.
  2. Tadalafil: It is found in strengths of 2.5 mg, 5 mg, 10 mg, and Tadarise 20 mg tablets. Usually, 10 mg is the starting dose, but like sildenafil, the amount can be changed as needed. There is also a low-dose form of tadalafil (2.5 mg or 5 mg) that can be taken once a day, whether or not you are sexually active.

Side Effects and Safety Profile of Sildenafil vs Tadalafil:

Sildenafil vs tadalafil have similar side effects, such as headaches, flushing of the face, upset stomach, stuffy nose, and feeling dizzy. Most of the time, these side effects are mild and short-lived.

Compared to Sildenafil vs tadalafil may cause more problems with vision, such as changes in color vision or blurred vision. 

Both drugs can cause more serious side effects, like priapism, which is a painful erection that lasts for a long time, sudden hearing loss, and sudden vision loss. These side effects are rare, but they need medical help right away.

Interactions with Food and Alcohol:

  • Comparison of the effects of sildenafil vs tadalafil on interactions with food and drink

  1. Sildenafil: Eating a high-fat meal before taking it can make it take longer to start working. 
  2. Tadalafil: Food has less of an effect on tadalafil than it does on sildenafil. But you shouldn’t drink too much alcohol because it can make side effects more likely.

Cost and Accessibility:

Both sildenafil vs tadalafil (sildenafil vs tadalafil)are available as generic drugs, which are usually less expensive than their brand-name versions.

On the other hand, when compared with sildenafil vs tadalafil, sildenafil is typically offered at a price that is lower than that of tadalafil.

Accessibility can also change based on what’s available in the area and whether or not a license is needed.

Choosing Between Sildenafil VS Tadalafil

When choosing between sildenafil vs tadalafil to treat erectile dysfunction, it’s important to think about what works best for you and your lifestyle. 

Sildenafil is taken right before sex, while a smaller dose of tadalafil can be taken every day, so you are always ready. Sildenafil is a good choice if you like to do things on the spur of the moment. If you like to be ready all the time, you might like tadalafil better.

How fast they work:

Sildenafil starts working in 30 to 60 minutes, while tadalafil may take 1 to 2 hours. 

Side effects: Both medicines can cause headaches and a stuffy nose, among other things. But everyone acts in a different way. Some people may have less trouble with side effects from one drug than another. 

Other medicines and health problems: Sildenafil vs tadalafil can combine with some medicines, so it is important to tell your doctor about everything you take. They will make sure nothing goes wrong.

Cost: The prices of the two drugs can be different, so you may also want to think about that.

-Individual Preferences and Lifestyle Factors:

After considering all the factors discussed above it is on a person’s choice to choose the one better suitable for their specific needs.

– Consultation with a Healthcare Professional:

Any blog or guide cannot replace a consultation with a professional. You should always consult with your doctor when it comes to making any healthcare-related choice.

Related – Which is Better, Sildenafil or Tadalafil?


As we have discussed throughout this blog, both Sildenafil vs Tadalafil are very effective drugs for ED. Both these generic drugs come with almost similar benefits and side effects. It’s a personal choice to decide in Sildenafil vs Tadalafil which one is more suitable for you, and of course, guiding blogs like this and health care professionals can help you in making the right choice


Tadalafil is thought to be a successful treatment for erectile dysfunction (ED). When compared to other ED drugs, tadalafil is recognised for having a longer half-life of effect, lasting up to 36 hours.

In general, tadalafil is safe for long-term usage when taken as directed and under a doctor’s supervision. But you should speak with your doctor first.

When used as directed by a medical expert, sildenafil, often known as Viagra, is typically safe for the heart. It’s crucial to speak with your doctor, especially if you have a history of heart disease.

Tadalafil can be used every day, but only with the advice and prescription of a medical practitioner.

No, it is not advised for women to use sildenafil or tadalafil. These drugs have not been approved by regulatory bodies to treat female sexual dysfunction; they are mostly used to treat erectile dysfunction in males.

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