Powerful Guide: Stendra for Erectile Dysfunction Treatment

Stendra, or Avanafil, is a drug used to treat erectile dysfunction (ED) in males. It’s a phosphodiesterase type 5 (PDE5) inhibitor that helps increase blood flow to penis, enabling men to achieve and maintain an erection during sexual stimulation.

S.NO.	Forms	About
1.	50 mg	Lower dose for patient who requires a small amount of medications.
2.	100 mg	Starting dose for most patients
3.	200 mg	Higher dose option available for those patients who require a stronger dose to achieve the desired effects.

Table of Contents

Key features:

Features
Active ingredients	Stendra or Avanafil
Available strength	50mg, 100mg, 200mg
Onset time	15-30 minutes
Duration of Action	4-6 hours

Inhibitor: Stendra (Avanafil) is a Phosphodiesterase type-5 (PDE5) inhibitor.

Mechanism of Action:

Stendra is a PDE5 inhibitor. It functions by:

Increasing blood flow: Stendra widens the blood vessels and smooth muscles of the penis, allowing more blood to pass through.
Erectile enhancement: The increased blood supply assists men in attaining and sustaining an erection upon sexual arousal.

Avanafil inhibits phosphodiesterase-5, preventing the degradation of cGMP.
The increased levels of cGMP cause vasodilation, resulting in an increased blood flow in the penis.
Avanafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for the degradation of cGMP in the corpus cavernosum located around the penis.
The increased levels of cGMP cause vasodilation, resulting in an increased blood flow in the penis.
Elevated cGMP level relaxes the smooth muscles and dilate blood vessels in penile region.
Sexual arousal results in the local release of nitric oxide, which in turn stimulates the enzyme guanylate cyclase to produce cGMP.

How fast does Stendra work?

Stendra (Avanafil) has a quick onset of action, generally beginning to take effect within:

15 minutes: The effects of Stendra can be felt by some men in just 15 minutes.
15-30 minutes: Stendra on average begins to have effects after 15-30 minutes of administration.
30-45 minutes: The drug is most effective between 30-40 minutes after administration.

Dosage:

Dosage as prescribed by physician i.e., 50 mg, 100 mg, or 200 mg can be taken approximately 30 minutes before sexual activity.
100 mg dose is mostly preferable.

Uses of Stendra:

Erectile Dysfunction: Stendra helps men achieve and maintain an erection during sexual stimulation.
Improving Sexual Function: Stendra enables men to have a more satisfying sexual experience by increasing blood flow.

Interaction:

Drug	Interaction
1,2-Benzodiazepine	Serum concentration of Avanafil can be increased.
Abaloparatide	Risk of severity of Hypotension can be increased.
Abametapir	Serum concentration of Avanafil can be increased.
Abatacept	Metabolism of Avanafil can be increased.
Abemaciclib	Serum concentration of Avanafil can be increased.

Side effects:

Headache
Flushing
Nasal congestion
Back Pain
Dizziness
Sinus Congestion
Upset Stomach

Stendra is well-tolerated, with most users experiencing minimal side effects that can vary in severity and impact from person to person.

Precautions:

Avoid alcohol while taking the Stendra medications.
Let your physician know if you have any heart, Kidney conditions, like Kidney or liver disease, heart failure, coronary artery disease, or recent myocardial infarction.
If you have a prolonged erection (over 4 hours), seek immediate medical care.